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Top 15 Famous People with Klinefelter Syndrome

Updated by Julius R in February 2024

*Originally published by Diana K on November 2022 Updated in November 2023 by Vanessa R

Klinefelter syndrome is a genetic condition that occurs as a result of a random inborn error after conception and results in a boy being born with an extra copy of the X chromosome, resulting in XXY as opposed to XY. This syndrome was first described in 1942 by Dr. Klinefelter, an endocrinologist at the Massachusetts General Hospital in Boston.  It affects males and is difficult to diagnose when the boy is still young thus, it is often diagnosed in adulthood. This condition affects one in 600 men and yet most people have never heard of it, including many who have it. Unfortunately, this condition has no cure. Treatment often for the health problems associated with this chromosomal condition. The other treatment available is testosterone replacement therapy. Medics also recommend language or speech therapy for children to help them achieve the right speech development.

Usually, symptoms are subtle making it hard to notice the condition. The primary features are infertility and small, poorly functioning testicles. Sometimes, symptoms are more evident and may include weaker muscles, greater height, poor motor coordination, less body hair, breast growth, and less interest in sex. Often, these symptoms are noticed only at puberty. Intelligence is usually normal, but reading difficulties and problems with speech are more common.

Individuals with Klinefelter syndrome are often affected psychologically and tend to have anxiety, depression, impaired social skills, behavioural problems such as emotional immaturity and impulsivity, attention-deficit/hyperactivity disorder (ADHD), and limited problem-solving skills. About 10 percent of boys and men with Klinefelter syndrome have autism spectrum disorder. There is also a lot of stigma around the condition and many people refuse to disclose that they have it meaning they do not get the support they need.

Let us have a look at some of the people who have publicly confirmed their diagnosis and others who are highly speculated to have the condition:

1. Lili Elbe

Lili Elbe. Image by unknown author-

She was a Danish transgender painter who specialized in landscape paintings and was among the early recipients of gender affirmation surgery. She was born in 1982 in Vejle, Denmark. It is speculated that she was intersex which has been disputed and other reports indicate that she had Klinefelter syndrome. Her partner, Gerda Gottlieb, was also an artist who illustrated books in fashion magazines. Elbe started wearing women’s clothes after she found she enjoyed the stockings and heels she wore to fill in for Gerda鈥檚 model that was late for a sitting. Lili was a name taken up after a suggestion by a friend. She had her first surgery in Germany and as the process was still experimental, a series of surgeries followed. Thereafter she legally changed her name but her marriage to Gerda was invalidated. She left the art world and once in an essay she expressed her dismay at society for only recognizing two sexes. Elbe and Gerda eventually broke up and she later got involved with a French art dealer, Claude Lejeune. Her last operation was in 1931 when they attempted to implant a uterus. She died due to severe complications of the surgery as it was still very experimental.

2. Brooke Moore

Brooke is a beauty blogger who identifies as a heterosexual transfemale. She was originally Bradley and was assigned the male gender at birth. As a child, she was often inclined towards Barbie dolls and Disney princesses, often seen in young girls. When she hit puberty at the age of 13, her body started changing, she began to develop breasts, she didn鈥檛 grow facial hair and her voice never broke. Being in an all-boys school was challenging as she was often bullied for being different. However, she was very strong and determined. She even went to the extent of wearing a full face of makeup and began to grow her hair. At the age of 16, she changed her name and everyone at this point thought of her as a girl. It was until her early twenties when she was diagnosed that she finally understood the changes her body was going through. She does not see the need for corrective surgery as she says that there is nothing to correct.

3. Caster Semenya

Caster Semenya. Photo by Tab59 from D眉sseldorf, Allemagne-

Semenya is a renowned South African athlete and an Olympic gold medalist. She is rumoured to have Klinefelter syndrome, especially due to her physical looks.  However, her diagnosis has never been made public. She has endured criticism, hatred, and an invasion of privacy over the years as many argue that she should not be allowed to compete with other women because of her high testosterone which gives her an upper hand. She has faced several challenges including undergoing a medical test in the pretense of a dope test and even being forced to take medication to lower her testosterone levels to compete. Together with her wife Violet they bore a child out of insemination.

4. Lauren Forster

This supermodel was raised in Durban, South Africa. She was only 4 years old when she knew she was living with the wrong gender. She was later diagnosed with Klinefelter syndrome. Her family was very supportive and went to recognize her as a girl. She did not face bullying or criticism as people knew her as a girl. She began receiving hormone therapy at 17 and a year later she underwent gender affirmation surgery. This angular cheek boned with piercing blue eyes became a successful model and took on the world. A tabloid released a story calling her a man. In as much as this would cripple just about anyone, Forster mustered the courage to own her gender identity and eventually found acceptance and continued to grace the glossy pages of the industry’s top fashion magazines. She uses her platform to advocate for the LGBTQ community.

5. Tom Cruise

Tom cruise. Image by Gage Skidmore-

Tom Cruise is one of the most famous and wealthiest actors in America. He has received many awards for his craft. It has been speculated for a very long time that Tom Cruise has Klinefelter syndrome but with no official backing. The basis of these speculations came from; his physical looks, he is tall, has wide hips and a rounded body type, he did not biologically father his three children, and he has dyslexia, which is another symptom of the condition.

6. Caroline Cossey

She was born on August 31, 1954, and was assigned male at birth under the name Barry Kenneth Cossey. This six-foot-striking former model made appearances throughout the 1970s, 1980s, and the 1990s. She was a very sought-after model for her beauty and she appeared in Playboy and was even given a brief cameo in a James Bond movie. A leaked tabloid broke the news to the world of a transgender after the film which gained her popularity internationally. At the age of 17, Cossey was officially diagnosed with Klinefelter syndrome and immediately started having hormone therapy. She finally underwent sex reassignment after saving money working as a topless dancer in Rome.

7. Veronique Francoise Caroline Renard

She is a famous Dutch author, actress, and visual artist. She took up the name Pantau, after meeting the Dalai Lama at an audience at her home in McLeodganj, Dharamsala, India in 2000. She was born as a male but underwent sexual reassignment in 1982 making her the youngest person to do this surgery in the Netherlands. She was officially diagnosed with Klinefelter syndrome at an early age. Her memoir, Pholomolo: No Man No Woman, portrays her struggles as a transgender woman. In the memoir, she describes several relationships she has been in many ending after her condition is disclosed. She also founded an organization, Pantau Foundation, which raises funds for the welfare of Tibetan refugees living in India.

8. Ren茅e Richards

Ren茅e Richards is an American ophthalmologist and former tennis player who competed on the professional circuit in the 1970s and became widely known following a sex reassignment surgery when she fought to compete as a woman in the 1976 US Open. She started to dress as a woman in college which was unheard of and she later adopted the name Renee which means reborn in French. Richards married model Barbara Mole in June 1970, and together they had a son Nicholas in 1972 but got divorced in 1975. She left her tennis career and decided to return to her medical practice, which she moved to Park Avenue in New York.

9. Janet Mock

Janet Mock. Image by Juston Smith-

Janet Mock is a famous American writer, TV producer and transgender rights activist. She is the author of the New York Times best-seller memoir 鈥淩edefining Realness鈥�. She has written on a variety of topics related to transgender women for Elle, Advocate, and People, and she also wrote, directed, and produced the popular LGBTQ series 鈥淧ose (2018)鈥� which bagged her a Primetime Emmy Award and Netflix鈥檚 series 鈥淗ollywood (2020)鈥�. There has never been an official confirmation of her having Klinefelter Syndrome as she has never commented on questions regarding the condition in all her interviews.

10. Jamie Lee Curtis

Jamee Lee Curtis. Image by Josh Hallett-

She is an American actress, author, blogger, and activist. She has appeared in several independent blockbuster films and has starred as a lead actress in various films accumulating $100 million. Though there has never been any official confirmation many speculate that she is a male born with Klinefelter syndrome and that her parents gave her a unisex name so that it could fit her whether she became a woman or not. Her refusal to comment on the condition in interviews furthered the rumors.

11. Charles Barkley

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Charles is an American retired professional basketball player who played for the Philadelphia 76ers, Phoenix Suns, and Houston Rockets in the National Basketball Association (NBA). He is an analyst on TNT’s Inside the NBA.

Barkley was diagnosed with Klinefelter syndrome as a child, but it did not stop him from becoming one of the greatest basketball players of all time. He is a two-time NBA MVP, a 10-time NBA All-Star, and a two-time Olympic gold medalist. He is a member of the Naismith Memorial Basketball Hall of Fame.

12. Michael Phelp

Michael is an American retired competitive swimmer, widely regarded as one of the greatest athletes of all time. He is the most decorated Olympian of all time, with 28 medals. Phelps was diagnosed with Klinefelter syndrome at the age of 16, but it did not prevent him from achieving his full potential.

He went on to win 23 gold medals at the Olympics, including eight at the 2008 Beijing Games. He is a member of the International Swimming Hall of Fame and the United States Olympic Hall of Fame.

13. Richard Branson 

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Richard is a British business magnate, investor, and author. He is the founder of the Virgin Group, which includes Virgin Atlantic, Virgin Records, and Virgin Galactic. Branson was diagnosed with Klinefelter syndrome as a child, but it has never stopped him from achieving his dreams. He is a self-made billionaire and one of the most successful entrepreneurs in the world. He is a member of the British Knighthood.

14. Tony Robins

Tony Robbins, an American author, philanthropist, and motivational speaker, founded the Robbins Research Institute in 1983. Born in Los Angeles in 1960, he was diagnosed with Klinefelter syndrome as a teenager but never gave up. He studied personal development principles, particularly those of NLP co-creators John Grinder and Richard Bandler, and used NLP to help people overcome fears and phobias. Robbins has written several books and produced documentaries and has been featured in publications like The New York Times, The Wall Street Journal, and Fortune.

He is a philanthropist, having donated millions to charities supporting education, poverty relief, and disaster relief. He is also the founder of the Anthony Robbins Foundation, which provides grants to organisations empowering people to reach their full potential. Robbins is a member of several boards of directors and has received the Horatio Alger Award for overcoming adversity. He is married to Sage Robbins and they have two children together.

15. Floyd Mayweather Jr

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Floyd Mayweather Jr. is a renowned professional boxer who retired undefeated in 50 fights and is widely considered one of the greatest boxers of all time. Despite being diagnosed with Klinefelter syndrome (KS) as a child, Mayweather never allowed it to affect his performance in the ring.

Although Mayweather has never publicly spoken about his KS diagnosis, it is believed to have contributed to his low testosterone levels and slight gynecomastia. Nevertheless, Mayweather has stated that his KS has given him a unique perspective on life and helped him become a more resilient and determined athlete. 

15 Facts about Klinefelter Syndrome: Understanding the Genetics and Diagnosis

1. Klinefelter Syndrome is characterized by the presence of an extra X chromosome

, Public domain, via Wikimedia Commons

Typically, males have one X and one Y chromosome (denoted as XY). But in those with Klinefelter syndrome, they possess an extra copy of the X chromosome (XXY karyotype). This extra genetic material arises randomly during the division of sex cells that go on to form the embryo or during early cell divisions right after fertilization. This additional X chromosome results in a variety of physical differences and health issues for affected boys and men.

The most common signs are small testes that produce little testosterone, enlarged breast tissue, less facial and body hair, weaker muscles, and infertility later in life. The extra X chromosome also impacts brain development and causes a higher chance of language disabilities, learning problems, anxiety, and social difficulties. While symptoms vary, early detection and management are important to improve one’s quality of life. Extra supports for physical, cognitive, and psychosocial health can make a big difference.

2. It occurs in around 1 in 500 to 1 in 1,000 newborn males

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Klinefelter Syndrome is not as rare as you might think 鈥� it’s actually one of the more common chromosomal disorders, affecting about 1 in every 500 to 1,000 newborn boys. To put it simply, if you gather a thousand baby boys together, it’s likely that one or two of them might have this condition. This prevalence showcases that while Klinefelter Syndrome is considered a disorder, it’s not extremely uncommon.

The extra X chromosome in XXY doesn’t follow the usual pattern of XY that most males have, and this difference occurs more frequently than many other chromosomal abnormalities. This fact underscores the importance of awareness and understanding about Klinefelter Syndrome, as it helps ensure timely diagnosis and appropriate support for those affected by this relatively common genetic condition.

3. The extra X chromosome usually comes from either the egg or the sperm

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Klinefelter syndrome is caused by a random event that leads to an extra copy of the X chromosome during the development of the fetus. Typically, females have two X chromosomes (XX) and males inherit one X from the mother and a Y chromosome from the father (XY). But in Klinefelter syndrome, there is one extra X chromosome that arises during either the formation of the egg or sperm or in the first few cell divisions after fertilization. If the extra X comes from the father’s sperm, it combines with the normal X chromosome from the mother’s egg during fertilization, resulting in a XXY embryo.

Similarly, if there is a random nondisjunction event during division of the mother’s egg, it may end up with two X’s that then combine with the father’s normal Y-contributing sperm. In either case, it is this abnormal addition of an X chromosome during or soon after conception that causes the constellation of symptoms known as Klinefelter syndrome. Detecting this extra X through karyotyping allows for both a definitive diagnosis and understanding of the chromosomal error underpinning the condition.

4. The severity of symptoms can vary widely among individuals with Klinefelter Syndrome

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Klinefelter Syndrome doesn’t play by a one-size-fits-all rule 鈥� the way it affects people can be quite different from one person to another. Imagine it like a spectrum 鈥� on one end, some folks might have mild symptoms, while on the other end, others might face more significant challenges. For some, the extra X chromosome might not cause noticeable issues or might only bring about mild changes, like being a bit taller than average.

On the flip side, some individuals might experience more noticeable effects, such as difficulties in learning or challenges during puberty. This variability makes each person’s experience unique. It’s like having a fingerprint 鈥� no two individuals with Klinefelter Syndrome are exactly alike. Understanding and acknowledging this range of experiences help doctors and families tailor support and interventions to meet the specific needs of each person with Klinefelter Syndrome.

5. The majority of individuals with Klinefelter Syndrome are infertile

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A hallmark feature of Klinefelter syndrome is small, firm testicles that produce lower-than-normal levels of testosterone from puberty onward. This testicular abnormality arises because the extra X chromosome gene dosage disrupts the early embryonic development of the gonads. The somatic cells of the testes contain the extra X chromosome, impairing their ability to properly nurture the germ cells that mature into sperm. As a result, most males with Klinefelter syndrome have marked germ cell loss and drastically reduced sperm production in the testes.

Without enough circulating testosterone and viable sperm, achieving fertility is extremely difficult for those affected. It is estimated that only 5-10% of men with Klinefelter syndrome are able to produce sperm capable of fertilizing an egg. For those desiring biologic children, assisted reproductive interventions can be attempted, though success rates remain low. But for many, coming to terms with infertility due to underdeveloped testes and nearly non-existent native sperm production is the painful reality of living with the effects of an extra X chromosome.

6. Language, learning, and reading disabilities occur more commonly among affected individuals

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In individuals with Klinefelter Syndrome, it’s not just about physical differences 鈥� there can be some challenges in the way they learn and communicate. Language, learning, and reading disabilities are more common among those with this condition. This means that some individuals might find it a bit tougher to grasp certain aspects of language or face difficulties in reading and learning compared to their peers. Social situations can also present some extra hurdles.

People with Klinefelter Syndrome might experience social difficulties, meaning they might find it a bit challenging to connect with others or understand social cues easily. Alongside this, anxiety disorders can be more frequent in individuals with Klinefelter Syndrome. So, not only is it about the physical aspects but also about navigating the social and emotional landscape, where extra support and understanding can make a significant difference in helping individuals lead fulfilling lives.

7. The extra X chromosome interferes with normal testicular development

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During embryonic development in males, the testes are critical endocrine glands that are responsible for producing hormones like testosterone that spark pubertal maturation. However, the additional genetic material from that extra X chromosome compromises early testicular architecture and integrity. Sertoli cells, which nurture sperm cell formation, appear to be especially sensitive and dysfunctional. As a result, the testes of boys with Klinefelter syndrome are smaller and consistent testosterone output is impaired.

Low testosterone from the testes delays growth of body hair, muscle mass, and genitals – classic hallmarks of puberty initiation. Many teens with Klinefelter thus face late and truncated puberty due to suboptimal testicular hormone production. While testosterone therapy can help augment virilization changes like a deeper voice, facial/body hair, etc., it cannot fully make up for underlying testicular dysfunction programmed in from embryonic life.

8. There is an increased risk of certain health conditions

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Having Klinefelter Syndrome not only brings about certain physical and developmental aspects but also comes with an increased risk of specific health conditions. One of these risks is osteoporosis, a condition where bones become weak and brittle. Individuals with Klinefelter Syndrome may be more prone to this, emphasizing the importance of bone health monitoring and care. Additionally, autoimmune disorders are more likely to occur in individuals with Klinefelter Syndrome.

These are conditions where the immune system mistakenly attacks the body’s own tissues, potentially leading to various health challenges. Lastly, there is an elevated risk of certain cancers. Regular health check-ups and screenings are crucial to catch any potential issues early on. Understanding and managing these additional health risks is a vital aspect of caring for individuals with Klinefelter Syndrome, ensuring that they receive appropriate medical attention and support throughout their lives.

9. Most people with Klinefelter are not diagnosed until adulthood, if ever

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Most people with Klinefelter are not diagnosed until adulthood, if ever. As children, symptoms can be sparse or subtle enough to avoid major medical or developmental interventions. Variability exists, but intelligence is usually normal to mildly impaired. Since language and learning difficulties are common to some degree in the general population, issues in those areas don鈥檛 spark genetic testing for most. Breast tissue enlargement during early puberty gets overlooked as simple gynecomastia. Even small testes can seem unremarkable, especially when virilization changes track normally as they do for 50% of adolescents with Klinefelter.

It is usually not until adulthood when more prominent symptoms emerge that evaluation is sought. The combination of small testes, low testosterone, infertility or sexual dysfunction, metabolic disorders, osteoporosis, etc. alongside a history then raises more suspicion. But since most adult men with Klinefelter have already adapted to longstanding physiologic and psychosocial differences, they perceive no need to confirm a chromosomal explanation. This results in stark underdiagnosis unless reproductive challenges or health conditions prompt inquiry.

10. Klinefelter Syndrome is not typically inherited from the father in the way many genetic conditions are passed down

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It’s important to clarify that Klinefelter Syndrome is not typically inherited from the father in the way many genetic conditions are passed down. Klinefelter Syndrome usually occurs as a result of a random event during the formation of sperm or egg cells. The presence of an extra X chromosome happens spontaneously. So, the idea that each son of a man with Klinefelter Syndrome has a 50% chance of inheriting the condition isn’t accurate.

In most cases, it’s not passed directly from the father to his sons. Instead, it’s a chance occurrence during the creation of reproductive cells. Each child of a man with Klinefelter Syndrome still has a 50% chance of being male (XY) and a 50% chance of being female (XX), but the extra X chromosome associated with Klinefelter Syndrome is not directly inherited from the father.

11. Testosterone replacement therapy (TRT) is often used to address hormonal imbalances and promote physical development

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Testosterone replacement can indeed help mitigate symptoms related to androgen deficiency that often emerges in adolescence or adulthood with Klinefelter syndrome. Since the syndrome is rooted in underlying testicular dysfunction, providing exogenous testosterone via gels, injections, or patches can boost virilization, muscle mass, energy levels, and mood. If begun around the expected age of puberty, testosterone can also promote development of facial, body, and pubic hair as well as genital maturation.

However, testosterone therapy cannot correct or prevent infertility caused by near complete absence of sperm production. The extra X chromosome and associated genes interfere early in embryonic testicular development, permanently disrupting the nurturing Sertoli and Leydig cells plus sperm progenitors. So while circulating testosterone may then rise to more normal levels via TRT, the spermatogenesis process itself remains obstructed. This means techniques like sperm retrieval for IVF or other assisted reproduction are unlikely to discover viable sperm for breeding.

12. Anxiety, depression, and social challenges are more common in individuals with KS

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13. While there’s no cure for KS, various treatments can address specific symptoms and improve quality of life

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14. Providing psychological and educational support to individuals with Klinefelter Syndrome and their families is crucial 

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15. Individuals with Klinefelter Syndrome (KS) can lead successful and fulfilling lives

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Individuals with Klinefelter Syndrome (KS) can lead successful and fulfilling lives. While they may face certain challenges associated with the condition, such as learning difficulties or social differences, many individuals with KS go on to achieve personal and professional success. With the right support, including educational assistance, psychosocial support, and medical interventions, individuals with KS can overcome obstacles and reach their full potential.

Success looks different for everyone, and it’s important to recognize and celebrate the unique strengths and achievements of each person with KS. Increased awareness and understanding of the condition contribute to creating inclusive environments that foster the success and well-being of individuals with Klinefelter Syndrome. By emphasizing their abilities, providing necessary support, and promoting inclusivity, we can help individuals with KS thrive in various aspects of their lives.

In conclusion, despite these obstacles, individuals like Tom Cruise have demonstrated resilience and achievement. Increased awareness is crucial to dismantling stigmas and fostering support. Emphasizing understanding and inclusivity, acknowledging the strengths of those with Klinefelter Syndrome, encourages a more compassionate society.